The study was conducted to evaluate the impact of epsom salt, rich in magnesium and sulfur content beneficial to plant, on beetroot production in aquaponics system. Media based aquaponics systems (nine units) were employed for beetroot and tilapia culture where three treatments T₁, T₂ and T₀ were applied with three replications (R₁, R₂, and R₃) each. Epsom salt was applied in T₁ as foliar spray in the form of 5% solution in each replication, whereas same amount of epsom salt (5 g) was directly applied on vegetable bed in T₂ as root application. But in control (T₀) no epsom salt was used. Beetroot saplings were planted in retrospect at a rate of two saplings per growbed (replication). After thirty days, plants grew enough to support the water clarification in aquaponics, ten tilapia fry were stocked per tank (90 L) in each replication. Fish were fed commercial floating feed containing 30% protein. Although the fish growth parameters in three treatments were statistically similar, the highest mean length gain, weight gain, specific growth rate and fish production were found 5.11±1.64 cm, 30.16±0.11 g, 0.39±0.01 %/day and 26.27±2.47 tons/ha/60 days respectively in T₁ followed by T₂ and T₀. However, response of beetroots to different treatments was statistically different. The highest average leaf area (69.79 ± 0.48 cm²), length of root (31.03±0.43 cm), weight of root (21.17±1.92 g), and production of beetroot 8.67±1.54 tons/ha/90 days were found in T₁ followed by T₂ and T₀. Harvesting time was also reduced in epsom salt based aquaponics system. The overall production of beetroot and tilapia was higher in T₁ (foliar spray) than T₂ (root application) and T₀ (control). Thus, the study signifies the potentialities of epsom salt in aquaponics vegetable production. However, further research is needed to verify the dose response to epsom salt in aquaponics system.