The experiment was conducted to visualize the effect of exogenous aspirin on tomato production in aquaponic system. Aspirin, a derivative of salicylic acid, acts as a potential non-enzymatic antioxidant and plant growth promoter, hence regulates plant physiology. The experiment employed three treatments (T) with three replications (R) each where, 60 ppm and 120 ppm aspirin were used in T₁ and T_2, respectively and T_con was control with no aspirin. Media filled plastic containers (0.29m×0.30m×0.21m) as growbeds and plastic tanks of 120 liter capacity as fish tank were installed to construct each aquaponic systems indicating each replication. Tilapia, was stocked at 111 fish /m³ in the fish tank and fed commercial floating feed containing 30% protein at the rate of 3% body weight twice daily. In each replication, two tomato saplings were planted. Fish tank water was oxygenated with a 10 watt air pump, then waste water from tank was pumped to grow bed with a 12 watt submersible pump. Survival rates were 70, 85 and 50% in T₁, T₂ and T_con respectively. While fish productions were 0.42, 0.34 and 40.49 (kg/m²/60 days) in T₁, T₂ and T_con respectively. The water quality parameters were within the suitable ranges for tilapia as well as tomato in the aquaponic system. Foliar spray of aspirin was applied fortnightly. Tomato production was hampered with various diseases in all the treatments although the aspirin treated plant (T₁ and T₂) were free from few diseases. The highest tomato production was found 0.44 kg/m²/60 days in T₂ followed by T₁ (0.42 kg/m²/60 days) and T_con (0.34 kg/m²/60 days). Noticeably, Plant growth and tomato production were higher in T₂ and T₁ with less disease prevalence than T_con, suggesting positive impacts of aspirin on tomato. However, further research is needed to justify the aspirin doses at user level.