Abstract not available

Listeria monocytogenes is a potentially lethal foodborne pathogen responsible for listeriosis, a serious and often invasive multisystem disease. This pathogen can infect a wide range of host tissues, leading to various clinical outcomes, from febrile gastroenteritis to severe complications such as sepsis, meningitis, and spontaneous abortions. Recognized as a human pathogen for over 80 years, L. monocytogenes presents an increasing public health challenge, especially in light of rising use of immunosuppressive therapies for cancer and other conditions, which has intensified infection risk among vulnerable individuals and elevated listeriosis prevalence in communities. Additionally, shifts in consumer behavior, with reduced time spent on food preparation and greater reliance on ready-to-eat and convenience foods, have heightened exposure risks. Advances in food production and preservation technologies have led to extended shelf-life products, often associated with increased Listeria risk. Addressing L. monocytogenes requires collective efforts from consumers, public health authorities, and the food industry. For effective disease monitoring, health authorities must implement a robust screening program to detect listeriosis cases, alongside regular characterization of isolates from human, food, and environmental sources. Integrating these data into shared databases is essential for tracking the pathogen and enforcing preventive measures.

Antibiotic therapy is essential in human and veterinary medicine, but resistance and prolonged exposure to antibiotic residues pose significant risks to health. This study investigated the long-term effects of amoxicillin residue on Swiss Albino male mice. Mice (n=20) were divided into control (no antibiotics) and treated (amoxicillin at the rate of 10 ppm in drinking water for one year; MRL 0.01 ppm) groups. Body weight, physical condition, immune status, blood parameters, ALT and AST enzyme levels, histopathology and residue accumulation in organs was examined. Antibiotics-treated mice exhibited significant weight gain (P<0.05~0.01) from the third month, peaking in the 10th month before declining. Treated mice appeared robust yet lethargic. Blood analysis showed decreased lymphocyte and neutrophil count and while no significant changes were observed in monocyte, eosinophil and basophils counts. ALT and AST levels were elevated but not statistically significant. Histopathology revealed liver steatosis, glomerular atrophy, and inflammatory cell infiltration in the liver and kidneys. TLC analysis confirmed Amoxicillin residue accumulation in the liver, kidneys, spleen, intestine, and muscles. The findings suggest that long-term exposure to antibiotic residues may adversely affect health and highlight the need for controlled antibiotic use to prevent potential hazards.